Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils
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چکیده
منابع مشابه
Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes
Leishmania species are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases. Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example, Leishmania species utilise host sphingolipid for synthesis of complex sphingolipid. In this study L. mexicana endocytosis was shown to be significantly upregulated in amastigotes, ind...
متن کاملDestruction of Leishmania mexicana amazonensis amastigotes within macrophages by lysosomotropic amino acid esters
Leishmania amastigotes parasitize almost exclusively the mononuclear phagocytes of mammals. The organisms survive and multiply within acidified vacuoles (parasitophorous vacuoles; p.v.) akin to phagolysosomes. Certain amino acid esters are known to accumulate in and disrupt lysosomes. We postulated that, since Leishmania possess lysosome-like organelles, they may be susceptible to the potential...
متن کاملDestruction of leishmania mexicana amazonensis amastigotes within macrophages in culture by phenazine methosulfate and other electron carriers
Exposure of macrophages infected with Leishmania mexicana amazonensis to phenazine methosulfate (PMS) resulted in rapid damage and disappearance of the intracellular amastigotes without obvious ill effects to the host cells. The reduction of the percent infection was related to the concentration of PMS and to the duration of the pulse. Most Leishmania disappeared within 2 h of a 2-h pulse with ...
متن کاملPurine nucleobase transport in amastigotes of Leishmania mexicana: involvement in allopurinol uptake.
Nucleobase and nucleoside transporters play central roles in the biochemistry of parasitic protozoa, as they lack the ability to synthesize purines de novo and are absolutely reliant upon purine salvage from their hosts. Furthermore, such transporters are potentially critical to the pharmacology of these important human pathogens, because they mediate the uptake of purine analogues, as well as ...
متن کاملProduction and characterization of stable amphotericin-resistant amastigotes and promastigotes of Leishmania mexicana.
The sensitivities of Leishmania mexicana amastigote and promastigote forms to amphotericin B were investigated in vitro and found to be strongly influenced by the culture media used. When differences in culture media were minimized, there was no significant difference in the 50% inhibitory concentration values between the two life cycle stages. Stable amphotericin B-resistant amastigote and pro...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2017
ISSN: 0741-5400,1938-3673
DOI: 10.1189/jlb.4hi0417-158r